HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Z-Leu-Asp-Leu-Ala-CH2Cl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Z-Leu-Asp(OtBu)-Leu-Ala-CH2Cl | HCID 131721136 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Z-Leu-Asp-Leu-Ala-CH2Cl | HCID 131721137 | 78.7% |
Reaction Steps
The Z-Leu-Asp(OtBu)-Leu-Ala-CH2Cl (0.653 g) in methylene chloride (5 mL) was stirred with trifluoroacetic acid (5 mL) at room temp for 2 h. After removal of the volatile species, the residue was triturated with diethyl ether to yield Z-Leu-Asp-Leu-Ala-CH2Cl as white powder (0.47 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06350573B1 |
| Source dataset | uspto-grants-2002_02 |
| ORD ID | ord-a6bf35dbfc174360a4cd8d0e2f32205b |
| Source note | uspto-grants-2002_02 |