HRID1700082

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

结构：CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)CCl

HCID131721136

未命名化合物

PRODUCTS

生成物

结构：CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)CCl

HCID131721137

未命名化合物

收率 78.7%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

The Z-Leu-Asp(OtBu)-Leu-Ala-CH2Cl (0.653 g) in methylene chloride (5 mL) was stirred with trifluoroacetic acid (5 mL) at room temp for 2 h. After removal of the volatile species, the residue was triturated with diethyl ether to yield Z-Leu-Asp-Leu-Ala-CH2Cl as white powder (0.47 g).

WORKUP

后处理

customAfter removal of the volatile species
customthe residue was triturated with diethyl ether

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a6bf35dbfc174360a4cd8d0e2f32205b
来源数据集: uspto-grants-2002_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06350573B1
来源说明: uspto-grants-2002_02

反应 SMILES

[NH:1]([C:36]([O:38][CH2:39][C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1)=[O:37])[C@H:2]([C:7]([NH:9][C@H:10]([C:19]([NH:21][C@H:22]([C:27]([NH:29][C@H:30]([C:32]([CH2:34][Cl:35])=[O:33])[CH3:31])=[O:28])[CH2:23][CH:24]([CH3:26])[CH3:25])=[O:20])[CH2:11][C:12](=[O:18])[O:13]C(C)(C)C)=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5].FC(F)(F)C(O)=O>C(Cl)Cl>[NH:1]([C:36]([O:38][CH2:39][C:40]1[CH:41]=[CH:42][CH:43]=[CH:44][CH:45]=1)=[O:37])[C@H:2]([C:7]([NH:9][C@H:10]([C:19]([NH:21][C@H:22]([C:27]([NH:29][C@H:30]([C:32]([CH2:34][Cl:35])=[O:33])[CH3:31])=[O:28])[CH2:23][CH:24]([CH3:26])[CH3:25])=[O:20])[CH2:11][C:12](=[O:13])[OH:18])=[O:8])[CH2:3][CH:4]([CH3:5])[CH3:6]