反应详情

A solution of N-({6-[(2,2-diphenylethyl)amino]-9-tetrahydro-2H-pyran-2-yl-9H-purin-2-yl}methyl)-2-methyl-1-propanesulfonamide (4.30 g, 7.84 mmol) (Preparation 7) in ethanol (100 ml) was heated to 37° C. and then treated with hydrochloric acid (2N, 15 ml). The mixture was left to stand at room temperature for 18 hours, after which time a crystalline precipitate was filtered off, washed with ethanol (10 ml) and dried to afford the title compound as a solid (3.0 g).

1. waitThe mixture was left
2. filtrationafter which time a crystalline precipitate was filtered off
3. washwashed with ethanol (10 ml)
4. customdried