5-Fluoroisatin → 5-fluoro-1,3-dihydro-2H-indol-2-one

HRID 1700197Notes

Reaction equation

HRID 1700197 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=O>O.NN>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2

Participants

3

Reactant 1

HCID 2365665-Fluoroisatin

Product 1

HCID 37310125-fluoro-1,3-dihydro-2H-indol-2-one

Reagents, catalysts & solvents 1

HCID 24654Hydrazine hydrate (1:1)Solvent

Procedure

5-Fluoroisatin (8.2 g) was dissolved in 50 mL of hydrazine hydrate and refluxed for 1.0 hr. The reaction mixtures were then poured in ice water. The precipitate was then filtered, washed with water and dried under vacuum oven afford the title compound.

Workup

  1. temperaturerefluxed for 1.0 hr
  2. customThe reaction mixtures
  3. filtrationThe precipitate was then filtered
  4. washwashed with water
  5. customdried under vacuum oven

Sources & evidence

ORD record
ord-77699b7ab8da411b99d677fe4faaeadf
Source dataset
uspto-grants-2002_02
Patent number
US06350754B2

Reaction notes

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