Hydrochloric Acid → HCID 70129420, compound

HRID 1700257Notes

Reaction equation

HRID 1700257 reaction equation
[O:1]1[CH2:6][CH2:5][C:4]([C:7]2([C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)=[CH:3][CH2:2]1.[ClH:18]>C(O)C.[Pt]=O>[ClH:18].[O:1]1[CH2:6][CH2:5][CH:4]([C:7]2([C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH2:3][CH2:2]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 18318088HCID 18318088, compound

Product 1

HCID 70129420HCID 70129420, compound

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 702EthanolSolvent

Procedure

To a suspension of platinum oxide (0.24 gm; 0.87 mmol) in ethanol (40 mL) and conc HCl (10 mL) was added the compound from Step B (0.41 gm; 1.71 mmol). The reaction mixture was purged with hydrogen and then shaken under a hydrogen atmosphere (50 psi) for 20 hours. The mixture was purged with nitrogen and filtered through celite and washed with EtOH and concentrated to give the title compound (0.36 gm) as a white solid.

Workup

  1. customThe reaction mixture was purged with hydrogen
  2. customThe mixture was purged with nitrogen
  3. filtrationfiltered through celite
  4. washwashed with EtOH
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-c7fd7d672b9f4816907ac7e86f9345df
Source dataset
uspto-grants-2002_02
Patent number
US06350760B1

Reaction notes

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