反应详情

温度

0 °C

To 3-cyano-6-((4-methoxybenzyl)oxy)-1-(2-formylethenyl)benzene (2.30 g) in 100 mL solution of CH2Cl2/MeOH/H2O (2:7:1) was added NaBH4 (0.29 g) at 0° C. The resulting solution was stirred at 0° C. for 1 hour and concentrated. The resulting residue was diluted with 100 mL of saturated aqueous NaHCO3 and extracted with ethyl acetate (3×). The organic layer was dried, concentrated to afford 3-cyano-6-((4-methoxybenzyl)oxy)-1-(3-hydroxyprop-2-en-1-yl)benzene (92.3 g) as a yellow solid.

1. concentrationconcentrated
2. additionThe resulting residue was diluted with 100 mL of saturated aqueous NaHCO3
3. extractionextracted with ethyl acetate (3×)
4. customThe organic layer was dried
5. concentrationconcentrated