Sodium Hydroxide → HCID 70155777, compound

HRID 1700337Notes

Reaction equation

HRID 1700337 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]2[C:13]([C:14]([O:16]CCC#N)=[O:15])=[C:12]([CH3:21])[NH:11][C:10]([CH:22]([O:25][CH3:26])[O:23][CH3:24])=[C:9]2[C:27](=[O:38])[NH:28][CH2:29][CH:30]=[CH:31][C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH:5]=[CH:6][CH:7]=1.[OH-].[Na+].S([O-])(O)(=O)=O.[K+]>CO>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]2[C:13]([C:14]([OH:16])=[O:15])=[C:12]([CH3:21])[NH:11][C:10]([CH:22]([O:23][CH3:24])[O:25][CH3:26])=[C:9]2[C:27](=[O:38])[NH:28][CH2:29][CH:30]=[CH:31][C:32]2[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=2)[CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 516920Potassium bisulfateHCID 70157899HCID 70157899, compound

Product 1

HCID 70155777HCID 70155777, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

134 mg (1.16 mmol) of 5-(2-cyanoethyl) 4-(3-chlorophenyl)-2-dimethoxymethyl-6-methyl-3-(3-phenyl-2-propene-1-ylcarbamoyl)-1,4-dihydropyridine-5-carboxylate was dissolved in 2.5 ml of methanol. 0.25 ml of 1 N aqueous sodium hydroxide solution was added to the obtained solution, and they were stirred at room temperature for 3 hours. An aqueous potassium hydrogensulfate solution was added to the reaction mixture. After the solvent was evaporated under reduced pressure, the residue was washed with water and then dried under reduced pressure to obtain the title compound.

Workup

  1. customAfter the solvent was evaporated under reduced pressure
  2. washthe residue was washed with water
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-5875074e80df4929b23fa5f00b0bb442
Source dataset
uspto-grants-2002_02
Patent number
US06350762B1

Reaction notes

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