Hydrochloric Acid → HCID 70156400, compound

HRID 1700355Notes

Reaction equation

HRID 1700355 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]2[C:13]([C:14](=[O:25])[NH:15][CH2:16][CH:17]=[CH:18][C:19]3[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=3)=[C:12]([CH3:26])[NH:11][C:10]([CH3:27])=[C:9]2[C:28]([O:30]CCC#N)=[O:29])[CH:5]=[CH:6][CH:7]=1.[OH-].[Na+].Cl>CO>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]2[C:13]([C:14](=[O:25])[NH:15][CH2:16][CH:17]=[CH:18][C:19]3[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=3)=[C:12]([CH3:26])[NH:11][C:10]([CH3:27])=[C:9]2[C:28]([OH:30])=[O:29])[CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 70157088HCID 70157088, compound

Product 1

HCID 70156400HCID 70156400, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

161 mg (0.338 mmol) of the compound obtained in Example 25 was dissolved in 10 ml of methanol. 0.372 ml of 1 N aqueous sodium hydroxide solution was added to the obtained solution, and they were stirred at room temperature for 4 hours. After the addition of 1 N hydrochloric acid, methanol was evaporated under reduced pressure. Water was added to the residue, and a precipitate thus formed was taken by the filtration and then recrystallized (recrystallization solvent: methanol/isopropyl ether) to obtain the title compound.

Workup

  1. customwas evaporated under reduced pressure
  2. additionWater was added to the residue
  3. customa precipitate thus formed
  4. filtrationwas taken by the filtration
  5. customrecrystallized
  6. custom(recrystallization solvent: methanol/isopropyl ether)

Sources & evidence

ORD record
ord-c14d46f07ea74f899b5c666f63318c0b
Source dataset
uspto-grants-2002_02
Patent number
US06350762B1

Reaction notes

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