反应详情

0.3 ml of methyl iodide and 0.8 g of NaHCO3 are added to a solution of 1 g of the compound of Example 1 in 25 ml of ethanol. After reaction for 24 hours at ambient temperature, the reaction mixture is concentrated under reduced pressure and then the residue is taken up in a mixture of water and dichloromethane. After extraction, drying and filtration, the organic phase is concentrated under reduced pressure. Crystallisation from a solution of ethanol and ethereal hydrogen chloride enables the expected product to be obtained.

1. customAfter reaction for 24 hours at ambient temperature
2. concentrationthe reaction mixture is concentrated under reduced pressure
3. additionthe residue is taken up in a mixture of water and dichloromethane
4. extractionAfter extraction
5. customdrying
6. filtrationfiltration
7. concentrationthe organic phase is concentrated under reduced pressure
8. customCrystallisation from a solution of ethanol and ethereal hydrogen chloride
9. customto be obtained