HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydroxyamine hydrochloride → HCID 88186782, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | 1-(6-Chloro-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)cyclobutanecarboxaldehyde | HCID 18317986 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 88186782 | HCID 88186782 | — |
Reaction Steps
A solution of 1.2 g of the compound obtained in Step A in 120 ml of ethanol, 0.54 ml of triethylamine and 0.27 g of hydroxylarnine hydrochloride is stirred for 6 hours and then concentrated under reduced pressure. Chromatography on silica gel (dichloromethane/ethyl acetate: 98/2) enables the expected product to be isolated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06350757B1 |
| Source dataset | uspto-grants-2002_02 |
| ORD ID | ord-33124569a369431e92c960347e745636 |
| Source note | uspto-grants-2002_02 |