Hydroxyamine hydrochloride → HCID 88186782, compound

HRID 1700381Notes

Reaction equation

HRID 1700381 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10]1[CH:9]([C:15]3([CH:19]=[O:20])[CH2:18][CH2:17][CH2:16]3)[NH:8][CH2:7][CH2:6][C:5]2=1.Cl.[NH2:22][OH:23]>C(O)C.C(N(CC)CC)C>[Cl:1][C:2]1[CH:3]=[C:4]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10]1[CH:9]([C:15]3([C:19]([NH:22][OH:23])=[O:20])[CH2:18][CH2:17][CH2:16]3)[NH:8][CH2:7][CH2:6][C:5]2=1

Participants

5

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 183179861-(6-Chloro-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)cyclobutanecarboxaldehyde

Product 1

HCID 88186782HCID 88186782, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8471TriethylamineSolvent

Procedure

A solution of 1.2 g of the compound obtained in Step A in 120 ml of ethanol, 0.54 ml of triethylamine and 0.27 g of hydroxylarnine hydrochloride is stirred for 6 hours and then concentrated under reduced pressure. Chromatography on silica gel (dichloromethane/ethyl acetate: 98/2) enables the expected product to be isolated.

Workup

  1. concentrationconcentrated under reduced pressure
  2. customto be isolated

Sources & evidence

ORD record
ord-33124569a369431e92c960347e745636
Source dataset
uspto-grants-2002_02
Patent number
US06350757B1

Reaction notes

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