Trifluoroacetic anhydride → HCID 18317950, compound

HRID 1700382Notes

Reaction equation

HRID 1700382 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10]1[CH:9]([C:15]3([C:19]([NH:21]O)=O)[CH2:18][CH2:17][CH2:16]3)[NH:8][CH2:7][CH2:6][C:5]2=1.O1CCOCC1.FC(F)(F)C(OC(=O)C(F)(F)F)=O>N1C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[C:4]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10]1[CH:9]([C:15]3([C:19]#[N:21])[CH2:18][CH2:17][CH2:16]3)[NH:8][CH2:7][CH2:6][C:5]2=1

Participants

5

Reactant 3

HCID 9845Trifluoroacetic anhydrideHCID 312751,4-DioxaneHCID 88186782HCID 88186782, compound

Product 1

HCID 18317950HCID 18317950, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

0.9 g of the compound obtained in Step B is stirred for 2 hours at ambient temperature in a solution of 10 ml of dioxane, 0.8 ml of pyridine and 0.42 ml of trifluoroacetic anhydride. After evaporating off the solvent, chromatography of the residue on silica gel (dichloromethane/ethyl acetate: 96/4) enables isolation of the expected product, which crystallises in heptane.

Workup

  1. customAfter evaporating off the solvent, chromatography of the residue on silica gel (dichloromethane/ethyl acetate: 96/4)
  2. customcrystallises in heptane

Sources & evidence

ORD record
ord-70696473b2d2465b9711534b663ae9c3
Source dataset
uspto-grants-2002_02
Patent number
US06350757B1

Reaction notes

Loading…