Hydrazine hydrate (1:1) → HCID 178424178, compound

HRID 1700448Notes

Reaction equation

HRID 1700448 reaction equation
O[C:2](=[C:4]1[C:9](=[O:10])[CH2:8][CH:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH3:17])[CH2:6][C:5]1=O)[CH3:3].O.[NH2:20][NH2:21]>C(O)C>[CH3:3][C:2]1[C:4]2[C:9](=[O:10])[CH2:8][CH:7]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[CH3:17])[CH2:6][C:5]=2[NH:21][N:20]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 178467252HCID 178467252, compound

Product 1

HCID 178424178HCID 178424178, compoundYield 90.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2-(1-hydroxyethylidene)-5-(2-methylphenyl)cyclohexane-1,3-dione (0.45 g) and hydrazine hydrate (0.1 g) in ethanol (10 ml) was refluxed for 15 minutes. Under reduced pressure, the solvent was evaporated, and the residue was recrystallized from ethyl acetate-hexane to give colorless crystals of 3-methyl-6-(2-methylphenyl)-4,5,6,7-tetrahydroindazol-4-one (0.40 g).

Workup

  1. customUnder reduced pressure, the solvent was evaporated
  2. customthe residue was recrystallized from ethyl acetate-hexane

Sources & evidence

ORD record
ord-59db1ed65c104096b60582f4be43a148
Source dataset
uspto-grants-2002_02
Patent number
US06350749B1

Reaction notes

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