Hydrazine hydrate (1:1) → HCID 178489315, compound

HRID 1700452Notes

Reaction equation

HRID 1700452 reaction equation
[C:1]([CH:4]1[C:9](=O)[CH2:8][CH:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[O:17][CH3:18])[CH2:6][C:5]1=[O:19])(=O)[CH3:2].O.[NH2:21][NH2:22]>C(O)C>[CH3:18][O:17][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[CH:7]1[CH2:8][C:9]2[NH:22][N:21]=[C:1]([CH3:2])[C:4]=2[C:5](=[O:19])[CH2:6]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 183173522-Acetyl-5-(2-methoxyphenyl)cyclohexane-1,3-dione

Product 1

HCID 178489315HCID 178489315, compoundYield 782%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2-acetyl-5-(2-methoxyphenyl)cyclohexane-1,3-dione (0.10 g) and hydrazine hydrate (0.21 g) in ethanol (20 ml) was refluxed for 30 minutes. Under reduced pressure, the solvent was evaporated, and the residue was recrystallized from ethyl acetate-hexane to give colorless crystals of 6-(2-methoxyphenyl)-3-methyl-4,5,6,7-tetrahydroindazol-4-one (0.77 g).

Workup

  1. customUnder reduced pressure, the solvent was evaporated
  2. customthe residue was recrystallized from ethyl acetate-hexane

Sources & evidence

ORD record
ord-6bccdd4915fd4812ae2154023937b078
Source dataset
uspto-grants-2002_02
Patent number
US06350749B1

Reaction notes

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