反应详情

A mixture of 5-(5-methyl-2-thienyl)cyclohexane-1,3-dione (4.16 g) and ammonium acetate (4.6 g) in ethanol (50 ml) was refluxed for 15 hours, and the reaction solution was concentrated under reduced pressure. To the residue was added water (60 ml), and the resulting crystals were filtered. The crystals were washed with water and toluene, and dried to give 1-amino-5-(5-methyl-2-thienyl)cyclohexen-3-one (3.37 g) as pale yellow crystals.

1. temperaturewas refluxed for 15 hours
2. concentrationthe reaction solution was concentrated under reduced pressure
3. additionTo the residue was added water (60 ml)
4. filtrationthe resulting crystals were filtered
5. washThe crystals were washed with water and toluene
6. customdried