Ammonium Acetate → HCID 18317628, compound

HRID 1700497Notes

Reaction equation

HRID 1700497 reaction equation
[CH3:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[CH:7]1[CH2:12][C:11](=O)[CH2:10][C:9](=[O:14])[CH2:8]1.C([O-])(=O)C.[NH4+:19]>C(O)C>[NH2:19][C:11]1[CH2:12][CH:7]([C:3]2[S:4][CH:5]=[CH:6][C:2]=2[CH3:1])[CH2:8][C:9](=[O:14])[CH:10]=1

Participants

4

Reactant 2

HCID 517165Ammonium AcetateHCID 183176325-(3-Methylthiophen-2-yl)cyclohexane-1,3-dione

Product 1

HCID 18317628HCID 18317628, compoundYield 90.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 5-(3-methyl-2-thienyl)-1,3-cyclohexanedione (3.0 g) and ammonium acetate (3.3 g) in ethanol (60 ml) was refluxed for 13 hours. Under reduced pressure, the solvent was evaporated, and to the residue were added ethyl acetate and water to precipitate crystals, which were filtered, washed with water and dried to give pale yellow crystals of 1-amino-5-(3-methyl-2-thienyl)cyclohexen-3-one (2.7 g).

Workup

  1. customUnder reduced pressure, the solvent was evaporated
  2. additionto the residue were added ethyl acetate and water
  3. customto precipitate crystals, which
  4. filtrationwere filtered
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-0fc25c4ade1f4ffe8201f981d3b736d6
Source dataset
uspto-grants-2002_02
Patent number
US06350749B1

Reaction notes

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