Hydrochloric Acid → HCID 178437243, compound

HRID 1700538Notes

Reaction equation

HRID 1700538 reaction equation
[CH2:1]([C:3]1[C:11]2[C:10](=O)[CH2:9][CH:8]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[CH2:7][C:6]=2[N:5]([S:19]([CH3:22])(=[O:21])=[O:20])[CH:4]=1)[CH3:2].[C:23]([NH:26][NH2:27])([NH2:25])=[NH:24].[ClH:28].Cl.O>C(O)C>[ClH:28].[CH2:1]([C:3]1[C:11]2[C:10](=[N:27][NH:26][C:23]([NH2:25])=[NH:24])[CH2:9][CH:8]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[CH2:7][C:6]=2[N:5]([S:19]([CH3:22])(=[O:21])=[O:20])[CH:4]=1)[CH3:2]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 18317347HCID 18317347, compoundHCID 178418668HCID 178418668, compound

Product 1

HCID 178437243HCID 178437243, compoundYield 284.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 3-ethyl-1-methanesulfonyl-6-phenyl-4,5,6,7-tetrahydroindol-4-one (0.25 g), aminoguanidine hydrochloride (0.091 g), concentrated hydrochloric acid (0.039 ml), water (0.039 ml) and ethanol (30 ml) was refluxed for 1 hour. Under reduced pressure, the solvent was evaporated, and the residue was washed with ethyl acetate and water to give 3-ethyl-4-guanidinoimino-1-methanesulfonyl-6-phenyl-4,5,6,7-tetrahydroindole hydrochloride (Compound 14) (0.92 g) as colorless crystals.

Workup

  1. temperaturewas refluxed for 1 hour
  2. customUnder reduced pressure, the solvent was evaporated
  3. washthe residue was washed with ethyl acetate and water

Sources & evidence

ORD record
ord-ca9130a9aa1f4fc688c31e292eca0c96
Source dataset
uspto-grants-2002_02
Patent number
US06350749B1

Reaction notes

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