反应详情

A mixture of 3-methyl-6-(2-chlorophenyl)-4,5,6,7-tetrahydroindazol-4-one (0.22 g), aminoguanidine hydrochloride (0.098 g), concentrated hydrochloric acid (0.084 ml), water (0.084 ml) and ethanol (40 ml) was refluxed for 4 hours. Under reduced pressure, the solvent was evaporated, and to the residue was added water. The mixture was washed with diethylether and concentrated under reduced pressure, and the resulting crystals were recrystallized from water-ethanol to give 4-guanidinoimino-6-(2-chlorophenyl)-3-methyl-4,5,6,7-tetrahydroindazole hydrochloride (Compound 21) (0.26 g) as colorless crystals.

1. temperaturewas refluxed for 4 hours
2. customUnder reduced pressure, the solvent was evaporated
3. additionto the residue was added water
4. washThe mixture was washed with diethylether
5. concentrationconcentrated under reduced pressure
6. customthe resulting crystals were recrystallized from water-ethanol