反应详情

A mixture of 6-(2-methoxyphenyl)-3-methyl-4,5,6,7-tetrahydroindazol-4-one (0.2 g), aminoguanidine hydrochloride (0.095 g), concentrated hydrochloric acid (0.12 ml), water (0.12 ml) and ethanol (30 ml) was refluxed for 1 hour. Under reduced pressure, the solvent was evaporated, and to the residue was added water. The mixture was washed with ethyl acetate and concentrated under reduced pressure, and the resulting crystals were recrystallized from water-ethanol to give 4-guanidinoimino-6-(2-methoxyphenyl)-3-methyl-4,5,6,7-tetrahydroindazole hydrochloride (Compound 25) (0.3 g) as colorless crystals.

1. temperaturewas refluxed for 1 hour
2. customUnder reduced pressure, the solvent was evaporated
3. additionto the residue was added water
4. washThe mixture was washed with ethyl acetate
5. concentrationconcentrated under reduced pressure
6. customthe resulting crystals were recrystallized from water-ethanol