反应详情

A mixture of 6-(2-hydroxyphenyl)-3-methyl-4,5,6,7-tetrahydroindazol-4-one (0.04 g), aminoguanidine hydrochloride (0.02 g), concentrated hydrochloric acid (0.041 ml), water (0.041 ml) and ethanol (10 ml) was refluxed for 3 hours. Under reduced pressure, the solvent was evaporated. To the residue was added water, and the mixture was washed with ethyl acetate. Under reduced pressure, the solvent was evaporated, and the resulting crystals were recrystallized from ethanol to give 4-guanidinoimino-6-(2-hydroxyphenyl)-3-methyl-4,5,6,7-tetrahydroindazole hydrochloride (Compound 26) (0.06 g) as colorless crystals.

1. temperaturewas refluxed for 3 hours
2. customUnder reduced pressure, the solvent was evaporated
3. additionTo the residue was added water
4. washthe mixture was washed with ethyl acetate
5. customUnder reduced pressure, the solvent was evaporated
6. customthe resulting crystals were recrystallized from ethanol