Hydrochloric Acid → HCID 178428111, compound

HRID 1700582Notes

Reaction equation

HRID 1700582 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:9]1[CH2:18][C:17]2[N:16]=[CH:15][CH:14]=[C:13]([CH3:19])[C:12]=2[C:11](=O)[CH2:10]1.[C:21]([NH:24][NH2:25])([NH2:23])=[NH:22].Cl.Cl>C(O)C>[ClH:1].[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:9]1[CH2:18][C:17]2[N:16]=[CH:15][CH:14]=[C:13]([CH3:19])[C:12]=2[C:11](=[N:25][NH:24][C:21]([NH2:23])=[NH:22])[CH2:10]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 10957724HCID 10957724, compoundHCID 178418668HCID 178418668, compound

Product 1

HCID 178428111HCID 178428111, compoundYield 213.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 7-(2,3-dichlorophenyl)-4-methyl-5,6,7,8-tetrahydroquinolin-5-one (306 mg), aminoguanidine hydrochloride (122 mg) and concentrated hydrochloric acid (0.2 ml) in ethanol (4 ml) was refluxed for 1 hour. The reaction solution was cooled, and precipitated crystals were filtered, washed with ethanol and dried to give 7-(2,3-dichlorophenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline hydrochloride (Compound 62) (425 mg) as colorless crystals.

Workup

  1. temperaturewas refluxed for 1 hour
  2. temperatureThe reaction solution was cooled
  3. customprecipitated crystals
  4. filtrationwere filtered
  5. washwashed with ethanol
  6. customdried

Sources & evidence

ORD record
ord-e82297133dee4bd88bf4ca59d7e88f2b
Source dataset
uspto-grants-2002_02
Patent number
US06350749B1

Reaction notes

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