反应详情

A mixture of 7-(2,6-dichlorophenyl)-4-methyl-5,6,7,8-tetrahydroquinolin-5-one (171 mg), aminoguanidine hydrochloride (67 mg) and concentrated hydrochloric acid (0.1 ml) in ethanol (3 ml) was refluxed for 2 hours. The reaction solution was concentrated under reduced pressure, and precipitated crystals were recrystallized form ethanol to give 7-(2,6-dichlorophenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline hydrochloride (Compound 63) (195 mg) as colorless crystals.

1. temperaturewas refluxed for 2 hours
2. concentrationThe reaction solution was concentrated under reduced pressure
3. customprecipitated crystals
4. customwere recrystallized form ethanol