反应详情

A mixture of 7-(2-hydroxyphenyl)-4-methyl-5,6,7,8-tetrahydroquinolin-5-one (0.08 g), aminoguanidine hydrochloride (0.037 g), concentrated hydrochloric acid (0.048 ml), water (0.048 ml) and ethanol (10 ml) was refluxed for 4 hours and cooled. Under reduced pressure, the solvent was evaporated, and the residue was dissolved in water. The solution was washed with ethyl acetate and concentrated under reduced pressure. The resulting crystals were washed with ethanol, while heating, to give 5-guanidinoimino-7-(2-hydroxyphenyl)-4-methyl-5,6,7,8-tetrahydroquinoline hydrochloride (Compound 68) (0.09 g) as colorless crystals.

1. temperaturewas refluxed for 4 hours
2. temperaturecooled
3. customUnder reduced pressure, the solvent was evaporated
4. dissolutionthe residue was dissolved in water
5. washThe solution was washed with ethyl acetate
6. concentrationconcentrated under reduced pressure
7. washThe resulting crystals were washed with ethanol
8. temperaturewhile heating