Hydrochloric Acid → HCID 178428129, compound

HRID 1700589Notes

Reaction equation

HRID 1700589 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]1[CH2:15][C:14]2[N:13]=[CH:12][CH:11]=[C:10]([CH3:16])[C:9]=2[C:8](=O)[CH2:7]1.[C:18]([NH:21][NH2:22])([NH2:20])=[NH:19].[ClH:23].Cl>C(O)C>[ClH:23].[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]1[CH2:15][C:14]2[N:13]=[CH:12][CH:11]=[C:10]([CH3:16])[C:9]=2[C:8](=[N:22][NH:21][C:18]([NH2:20])=[NH:19])[CH2:7]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 109552977-(2-Furyl)-4-methyl-5,6,7,8-tetrahydroquinolin-5-oneHCID 178418668HCID 178418668, compound

Product 1

HCID 178428129HCID 178428129, compoundYield 95.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 7-(2-furyl)-4-methyl-5,6,7,8-tetrahydroquinolin-5-one (227 mg), aminoguanidine hydrochloride (122 mg) and concentrated hydrochloric acid (0.1 ml) in ethanol (3 ml) was refluxed for 2 hours. The reaction solution was cooled, and precipitated crystals were filtered and washed with ethanol to give 7-(2-furyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline hydrochloride (Compound 69) (305 mg) as colorless crystals.

Workup

  1. temperaturewas refluxed for 2 hours
  2. temperatureThe reaction solution was cooled
  3. customprecipitated crystals
  4. filtrationwere filtered
  5. washwashed with ethanol

Sources & evidence

ORD record
ord-0e22c3234abf4fabb3f7fe318af2b76b
Source dataset
uspto-grants-2002_02
Patent number
US06350749B1

Reaction notes

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