反应详情

A mixture of 7-(4-fluorophenyl)-4-methyl-5,6,7,8-tetrahydroquinolin-5-one (0.2 g), aminoguanidine hydrochloride (0.091 g), concentrated hydrochloric acid (0.2 ml), water (0.2 ml) and ethanol (30 ml) was refluxed for 5 hours. Under reduced pressure, the solvent was evaporated, and the residue was dissolved in water. The solution was washed with ethyl acetate. Under reduced pressure, the solvent was evaporated, and the residue was recrystallized from ethanol-ethyl acetate and then recrystallized from ethanol-water to give 7-(4-fluorophenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline hydrochloride (Compound 77) (0.17 g) as colorless crystals.

1. temperaturewas refluxed for 5 hours
2. customUnder reduced pressure, the solvent was evaporated
3. dissolutionthe residue was dissolved in water
4. washThe solution was washed with ethyl acetate
5. customUnder reduced pressure, the solvent was evaporated
6. customthe residue was recrystallized from ethanol-ethyl acetate
7. customrecrystallized from ethanol-water