反应详情

A mixture of 2-methyl-7-(2-methylphenyl)-5,6,7,8-tetrahydroquinolin-5-one (0.3 g), aminoguanidine hydrochloride (0.26 g), concentrated hydrochloric acid (0.12 ml), water (0.12 ml) and ethanol (30 ml) was refluxed for 2.5 hours. Under reduced pressure, the solvent was evaporated, and the residue was dissolved in water. The solution was washed with diethylether, and to the solution was added sodium hydrogen carbonate solution. The mixture was extracted with ethyl acetate, and the organic layer was washed with water and saturated brine, and dried with magnesium sulfate. Under reduced pressure, the solvent was evaporated, and the residue was dissolved in ethanol. To the solution was added 1N hydrochloric acid (2.5 ml), and the solvent was evaporated. The residue was washed with ethanol to give 5-guanidinoimino-2-methyl-7-(2-methylphenyl)-5,6,7,8-tetrahydroquinoline hydrochloride (Compound 88) (0.32 g) as colorless crystals.

1. temperaturewas refluxed for 2.5 hours
2. customUnder reduced pressure, the solvent was evaporated
3. dissolutionthe residue was dissolved in water
4. washThe solution was washed with diethylether
5. additionto the solution was added sodium hydrogen carbonate solution
6. extractionThe mixture was extracted with ethyl acetate
7. washthe organic layer was washed with water and saturated brine
8. dry with materialdried with magnesium sulfate
9. customUnder reduced pressure, the solvent was evaporated
10. dissolutionthe residue was dissolved in ethanol
11. additionTo the solution was added 1N hydrochloric acid (2.5 ml)
12. customthe solvent was evaporated
13. washThe residue was washed with ethanol