Hydrochloric Acid → HCID 178428146, compound

HRID 1700619Notes

Reaction equation

HRID 1700619 reaction equation
[Cl:1][C:2]1[S:3][CH:4]=[CH:5][C:6]=1[CH:7]1[CH2:16][C:15]2[N:14]=[CH:13][CH:12]=[C:11]([CH3:17])[C:10]=2[C:9](=O)[CH2:8]1.[C:19]([NH:22][NH2:23])([NH2:21])=[NH:20].Cl.Cl>C(O)C>[ClH:1].[Cl:1][C:2]1[S:3][CH:4]=[CH:5][C:6]=1[CH:7]1[CH2:16][C:15]2[N:14]=[CH:13][CH:12]=[C:11]([CH3:17])[C:10]=2[C:9](=[N:23][NH:22][C:19]([NH2:21])=[NH:20])[CH2:8]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 10891160HCID 10891160, compoundHCID 178418668HCID 178418668, compound

Product 1

HCID 178428146HCID 178428146, compoundYield 151%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
90 °C

Procedure

A mixture of 7-(2-chlorothiophen-3-yl)-4-methyl-5,6,7,8-tetrahydroquinolin-5-one (147 mg), aminoguanidine hydrochloride (63 mg) and concentrated hydrochloric acid (0.1 ml) in ethanol (3 ml) was stirred at 90° C. (bath temperature) for 14 hours. The reaction solution was cooled, and precipitated crystals were filtered, washed with ethanol and dried to give 7-(2-chlorothiophen-3-yl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline hydrochloride (Compound 101) (148 mg) as colorless crystals.

Workup

  1. temperatureThe reaction solution was cooled
  2. customprecipitated crystals
  3. filtrationwere filtered
  4. washwashed with ethanol
  5. customdried

Sources & evidence

ORD record
ord-66c5246ccb8449319aa9480dffe21b18
Source dataset
uspto-grants-2002_02
Patent number
US06350749B1

Reaction notes

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