反应详情

温度

90 °C

To a mixture of 3-carbamoyl-6-phenyl-4,5,6,7-tetrahydrobenzofuran-4-one (0.24 g) and aminoguanidine hydrochloride (104 mg) were added ethanol (20 ml) and 6N hydrochloric acid (0.081 ml), and the mixture was stirred at 90° C. for 2 hours and cooled. Precipitated crystals were washed with ethanol and isopropylether, and dried to give (E)-3-carbamoyl-4-guanidinoimino-6-phenyl-4,5,6,7-tetrahydrobenzofuran hydrochloride (Compound 107) (0.28 g).

1. temperaturecooled
2. customPrecipitated crystals
3. washwere washed with ethanol and isopropylether
4. customdried