Hydrazine hydrate (1:1) → HCID 178434194, compound

HRID 1700631Notes

Reaction equation

HRID 1700631 reaction equation
[Cl:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[CH:7]1[CH2:12][C:11](=O)[C:10](=[C:14](O)[CH3:15])[C:9](=[O:17])[CH2:8]1.O.[NH2:19][NH2:20]>C(O)C>[Cl:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[CH:7]1[CH2:12][C:11]2[NH:20][N:19]=[C:14]([CH3:15])[C:10]=2[C:9](=[O:17])[CH2:8]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 178467260HCID 178467260, compound

Product 1

HCID 178434194HCID 178434194, compoundYield 60%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 5-(3-chlorothiophen-2-yl)-2-(1-hydroxyethylidene)-cyclohexane-1,3-dione (2.2 g) and hydrazine hydrate (0.45 g) in ethanol (60 ml) was refluxed for 2 hours. Under reduced pressure, the solvent was evaporated, and the residue was recrystallized from ethyl acetate-hexane to give colorless crystals of 6-(3-chlorothiophen-2-yl)-3-methyl-4,5,6,7-tetrahydroindazol-4-one (1.3 g).

Workup

  1. customUnder reduced pressure, the solvent was evaporated
  2. customthe residue was recrystallized from ethyl acetate-hexane

Sources & evidence

ORD record
ord-fd788aef6f494e23aaccfd92d7cf4596
Source dataset
uspto-grants-2002_02
Patent number
US06350749B1

Reaction notes

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