反应详情

To (−)-7-(2,5-dichlorothiophen-3-yl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline (6.4 g) was added ethanol (50 ml) and methanesulfonic acid (3.1 g) to give a homogenous solution, and the solution was concentrated to give crystals, which were recrystallized from ethanol to give (−)-7-(2,5-dichlorothiophen-3-yl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline methanesulfonate (Compound 113) (8.1 g,99.5% ee).

1. customto give a homogenous solution
2. concentrationthe solution was concentrated
3. customto give crystals, which
4. customwere recrystallized from ethanol