Methanesulfonic Acid → HCID 178505257, compound

Participants

Reaction Steps

To a solution of (−)-7-(2,5-dichlorothiophen-3-yl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline (0.8 g) in ethanol (20 ml) was added methanesulfonic acid (0.37 g), and the mixture was concentrated under reduced pressure. To the residue was added water (1 ml), and the mixture was concentrated to precipitate crystals, which were filtered and washed with ethanol. The thus obtained crystals were dried to give (−)-7-(2,5-dichlorothiophen-3-yl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline methanesulfonate monohydrate (Compound 114) (1.0 g).

Provenance & Evidence