反应详情

To a solution of (−)-7-(2,5-dichlorothiophen-3-yl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline (0.8 g) in ethanol (20 ml) was added methanesulfonic acid (0.37 g), and the mixture was concentrated under reduced pressure. To the residue was added water (1 ml), and the mixture was concentrated to precipitate crystals, which were filtered and washed with ethanol. The thus obtained crystals were dried to give (−)-7-(2,5-dichlorothiophen-3-yl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline methanesulfonate monohydrate (Compound 114) (1.0 g).

1. concentrationthe mixture was concentrated under reduced pressure
2. additionTo the residue was added water (1 ml)
3. concentrationthe mixture was concentrated
4. customto precipitate crystals, which
5. filtrationwere filtered
6. washwashed with ethanol
7. customThe thus obtained crystals were dried