反应详情

To a solution of (−)-7-(2,5-dichlorothiophen-3-yl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline (0.8 g) in ethanol (20 ml) was added 1.7M nitric acid (2.3 ml), and the mixture was concentrated under reduced pressure to give crystals, which were recrystallized from water to give (−)-7-(2,5-dichlorothiophen-3-yl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline nitrate (Compound 116) (0.92 g).

1. concentrationthe mixture was concentrated under reduced pressure
2. customto give crystals, which
3. customwere recrystallized from water