Hydrochloric Acid → HCID 178434185, compound

HRID 1700662Notes

Reaction equation

HRID 1700662 reaction equation
[Cl:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[CH:7]1[CH2:15][C:14]2[NH:13][N:12]=[C:11]([CH3:16])[C:10]=2[C:9](=O)[CH2:8]1.[C:18]([NH:21][NH2:22])([NH2:20])=[NH:19].Cl.Cl.O>C(O)C>[ClH:1].[Cl:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[CH:7]1[CH2:15][C:14]2[NH:13][N:12]=[C:11]([CH3:16])[C:10]=2[C:9](=[N:22][NH:21][C:18]([NH2:20])=[NH:19])[CH2:8]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 178418668HCID 178418668, compoundHCID 178434194HCID 178434194, compound

Product 1

HCID 178434185HCID 178434185, compoundYield 148.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 6-(3-chloro-2-thienyl)-3-methyl-4,5,6,7-tetrahydroindazol-4-one (1.2 g), aminoguanidine hydrochloride (0.6 g), concentrated hydrochloric acid (1.1 ml), water (1.1 ml) and ethanol (50 ml) was refluxed for 3 hours. Under reduced pressure, the solvent was evaporated, and the residue was washed with ethanol to give 6-(3-chloro-2-thienyl)-4-guanidinoimino-3-methyl-4,5,6,7-tetrahydroindazole hydrochloride (Compound 119) (1.2 g) as colorless crystals.

Workup

  1. temperaturewas refluxed for 3 hours
  2. customUnder reduced pressure, the solvent was evaporated
  3. washthe residue was washed with ethanol

Sources & evidence

ORD record
ord-b83868e4d88f45c1a8878818a2e9b9ea
Source dataset
uspto-grants-2002_02
Patent number
US06350749B1

Reaction notes

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