Hydrochloric Acid → HCID 178434184, compound

HRID 1700670Notes

Reaction equation

HRID 1700670 reaction equation
[Cl:1][C:2]1[S:3][C:4]([Cl:18])=[CH:5][C:6]=1[CH:7]1[CH2:15][C:14]2[NH:13][N:12]=[C:11]([CH3:16])[C:10]=2[C:9](=O)[CH2:8]1.[C:19]([NH:22][NH2:23])([NH2:21])=[NH:20].Cl.Cl>C(O)C>[ClH:1].[Cl:1][C:2]1[S:3][C:4]([Cl:18])=[CH:5][C:6]=1[CH:7]1[CH2:15][C:14]2[NH:13][N:12]=[C:11]([CH3:16])[C:10]=2[C:9](=[N:23][NH:22][C:19]([NH2:21])=[NH:20])[CH2:8]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 178418668HCID 178418668, compoundHCID 178434193HCID 178434193, compound

Product 1

HCID 178434184HCID 178434184, compoundYield 209.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a mixture of 6-(2,5-dichlorothiophen-3-yl)-3-methyl-4,5,6,7-tetrahydroindazol-4-one (0.3 g) and aminoguanidine hydrochloride (122 mg) were added ethanol (5 ml) and concentrated hydrochloric acid (0.1 ml), and the mixture was refluxed for 4 hours and cooled. Precipitated crystals were filtered, washed with ethanol and dried to give 6-(2,5-dichlorothiophen-3-yl)-4-guanidinoimino-3-methyl-4,5,6,7-tetrahydroindazole hydrochloride (Compound 127) (0.41 g) as pale yellow crystals.

Workup

  1. temperaturethe mixture was refluxed for 4 hours
  2. temperaturecooled
  3. customPrecipitated crystals
  4. filtrationwere filtered
  5. washwashed with ethanol
  6. customdried

Sources & evidence

ORD record
ord-3a1f240206a64599be7e6c52ac815d5e
Source dataset
uspto-grants-2002_02
Patent number
US06350749B1

Reaction notes

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