Hydrochloric Acid → HCID 178430923, compound

HRID 1700672Notes

Reaction equation

HRID 1700672 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:17][C:16]2[N:15]=[N:14][CH:13]=[C:12]([CH3:18])[C:11]=2[C:10](=O)[CH2:9]1.[C:20]([NH:23][NH2:24])([NH2:22])=[NH:21].Cl.Cl>C(O)C>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:17][C:16]2[N:15]=[N:14][CH:13]=[C:12]([CH3:18])[C:11]=2[C:10](=[N:24][NH:23][C:20]([NH2:22])=[NH:21])[CH2:9]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 110439264-Methyl-7-(2-chlorophenyl)-5,6,7,8-tetrahydrocinnolin-5-oneHCID 178418668HCID 178418668, compound

Product 1

HCID 178430923HCID 178430923, compoundYield 174.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a mixture of 7-(2-chlorophenyl)-4-methyl-5,6,7,8-tetrahydrocinnolin-5-one (0.218 g) and aminoguanidine hydrochloride (94 mg) were added ethanol (5 ml) and concentrated hydrochloric acid (0.1 ml), and the mixture was refluxed for 1.5 hours and cooled. Precipitated crystals were filtered, washed with ethanol and dried to give 7-(2-chlorophenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydrocinnoline hydrochloride (Compound 129) (0.255 g) as crystals.

Workup

  1. temperaturethe mixture was refluxed for 1.5 hours
  2. temperaturecooled
  3. customPrecipitated crystals
  4. filtrationwere filtered
  5. washwashed with ethanol
  6. customdried

Sources & evidence

ORD record
ord-ed671daf92df4a358bd9e0cdbf895f68
Source dataset
uspto-grants-2002_02
Patent number
US06350749B1

Reaction notes

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