Hydrochloric Acid → HCID 178430928, compound

HRID 1700673Notes

Reaction equation

HRID 1700673 reaction equation
[CH3:1][C:2]1[C:11]2[C:10](=O)[CH2:9][CH:8]([C:13]3[CH:17]=[CH:16][S:15][CH:14]=3)[CH2:7][C:6]=2[N:5]=[N:4][CH:3]=1.[C:18]([NH:21][NH2:22])([NH2:20])=[NH:19].[ClH:23].Cl>C(O)C>[ClH:23].[NH:21]([N:22]=[C:10]1[CH2:9][CH:8]([C:13]2[CH:17]=[CH:16][S:15][CH:14]=2)[CH2:7][C:6]2[N:5]=[N:4][CH:3]=[C:2]([CH3:1])[C:11]1=2)[C:18]([NH2:20])=[NH:19]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 18317595HCID 18317595, compoundHCID 178418668HCID 178418668, compound

Product 1

HCID 178430928HCID 178430928, compoundYield 96.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a mixture of 4-methyl-7-(thiophen-3-yl)-5,6,7,8-tetrahydrocinnolin-5-one (0.195 g) and aminoguanidine hydrochloride (94 mg) were added ethanol (5 ml) and concentrated hydrochloric acid (0.1 ml), and the mixture was refluxed for 1.5 hours and cooled. Precipitated crystals were filtered, washed with ethanol and dried to give 5-guanidinoimino-4-methyl-7-(thiophen-3-yl)-5,6,7,8-tetrahydrocinnoline hydrochloride (Compound 130) (0.26 g) as colorless crystals.

Workup

  1. temperaturethe mixture was refluxed for 1.5 hours
  2. temperaturecooled
  3. customPrecipitated crystals
  4. filtrationwere filtered
  5. washwashed with ethanol
  6. customdried

Sources & evidence

ORD record
ord-56ae7088c99449beab6dcd6e82034fb0
Source dataset
uspto-grants-2002_02
Patent number
US06350749B1

Reaction notes

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