Acetone → 4-(5-Chloro-2-methylphenyl)-3-buten-2-one

HRID 1700721노트

반응식

HRID 1700721 반응식
[OH-].[Na+].O.[Cl:4][C:5]1[CH:6]=[CH:7][C:8]([CH3:13])=[C:9]([CH:12]=1)[CH:10]=O.[CH3:14][C:15]([CH3:17])=[O:16]>>[Cl:4][C:5]1[CH:6]=[CH:7][C:8]([CH3:13])=[C:9]([CH:10]=[CH:14][C:15](=[O:16])[CH3:17])[CH:12]=1

참가 물질

5

반응물 4

HCID 180Acetone2회HCID 962WaterHCID 14798Sodium HydroxideHCID 123475655-Chloro-2-methylbenzaldehyde

생성물 1

HCID 536366744-(5-Chloro-2-methylphenyl)-3-buten-2-one

실험 절차

To a mixture of acetone (80 ml), sodium hydroxide (1.2 g) and water (80 ml) was added dropwise at 0° C. a solution of 5-chloro-2-methylbenzaldehyde (4.1 g) in acetone (10 ml), and the mixture was stirred at the same temperature for 1 hour. Under reduced pressure, acetone was evaporated, and the residue was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, and concentrated under reduced pressure to give 4-(5-chloro-2-methylphenyl)-3-buten-2-one (5.5 g) as oil.

후처리

  1. customUnder reduced pressure, acetone was evaporated
  2. extractionthe residue was extracted with ethyl acetate
  3. washThe organic layer was washed with water and saturated brine
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-562f1f07f3f048b8b6b0f1b731aa8952
출처 데이터셋
uspto-grants-2002_02
특허 번호
US06350749B1

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