Sodium Methoxide → HCID 178428150, compound

HRID 1700730Notes

Reaction equation

HRID 1700730 reaction equation
Cl.[Cl:2][C:3]1[CH:7]=[C:6]([Cl:8])[S:5][C:4]=1[CH:9]1[CH2:18][C:17]2[N:16]=[CH:15][CH:14]=[C:13]([CH3:19])[C:12]=2[C:11](=[N:20][NH:21][C:22]([NH2:24])=[NH:23])[CH2:10]1.C[O-].[Na+]>CO>[Cl:2][C:3]1[CH:7]=[C:6]([Cl:8])[S:5][C:4]=1[CH:9]1[CH2:18][C:17]2[N:16]=[CH:15][CH:14]=[C:13]([CH3:19])[C:12]=2[C:11](=[N:20][NH:21][C:22]([NH2:24])=[NH:23])[CH2:10]1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 178428151HCID 178428151, compound

Product 1

HCID 178428150HCID 178428150, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Conditions

Temperature
50 °C

Procedure

To a solution of (±)-7-(3,5-dichlorothiophen-2-yl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline hydrochloride (3.0 g) in methanol (30 ml) was added a solution of 28% sodium methoxide in methanol (3 g), and the mixture was stirred at 50° C. for 1 hour. Under reduced pressure, the solvent was evaporated, and to the residue was added water. Precipitated crystals were washed with water and dried to give (±)-7-(3,5-dichlorothiophen-2-yl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline.

Workup

  1. customUnder reduced pressure, the solvent was evaporated
  2. additionto the residue was added water
  3. customPrecipitated crystals
  4. washwere washed with water
  5. customdried

Sources & evidence

ORD record
ord-7a2f25252d0a42ccbeb65c085b04b8ae
Source dataset
uspto-grants-2002_02
Patent number
US06350749B1

Reaction notes

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