Sodium Methoxide → HCID 178428150, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (±)-7-(3,5-dichlorothiophen-2-yl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline hydrochloride (3.0 g) in methanol (30 ml) was added a solution of 28% sodium methoxide in methanol (3 g), and the mixture was stirred at 50° C. for 1 hour. Under reduced pressure, the solvent was evaporated, and to the residue was added water. Precipitated crystals were washed with water and dried to give (±)-7-(3,5-dichlorothiophen-2-yl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline.

Provenance & Evidence