Hydrochloric Acid → HCID 178430929, compound

HRID 1700743Notes

Reaction equation

HRID 1700743 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:17][C:16]2[N:15]=[N:14][CH:13]=[C:12]([CH3:18])[C:11]=2[C:10](=O)[CH2:9]1.Cl.[NH2:21][NH:22][C:23]([NH:25][OH:26])=[NH:24].Cl>C(O)C>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:17][C:16]2[N:15]=[N:14][CH:13]=[C:12]([CH3:18])[C:11]=2[C:10](=[N:21][NH:22][C:23](=[NH:24])[NH:25][OH:26])[CH2:9]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 110439264-Methyl-7-(2-chlorophenyl)-5,6,7,8-tetrahydrocinnolin-5-oneHCID 178479533HCID 178479533, compound

Product 1

HCID 178430929HCID 178430929, compoundYield 155.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
90 °C

Procedure

To a mixture of 7-(2-chlorophenyl)-4-methyl-5,6,7,8-tetrahydrocinnolin-5-one (101 mg) and 1-amino-3-hydroxyguanidine hydrochloride (48 mg) were added ethanol (2 ml) and concentrated hydrochloric acid (0.05 ml), and the mixture was stirred at 90° C. for 1.5 hours. The reaction solution was concentrated under reduced pressure, and the residue was washed with ethanol and dried to give 7-(2-chlorophenyl)-5-(1-hydroxyguanidin-3-yl)imino-4-methyl-5,6,7,8-tetrahydrocinnoline hydrochloride (Compound 156) (110 mg) as gray white crystals.

Workup

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. washthe residue was washed with ethanol
  3. customdried

Sources & evidence

ORD record
ord-74945a8e986c4309b9c1fccf668ebf59
Source dataset
uspto-grants-2002_02
Patent number
US06350749B1

Reaction notes

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