Hydrochloric Acid → HCID 178428121, compound

HRID 1700762Notes

Reaction equation

HRID 1700762 reaction equation
Cl.[Cl:2][C:3]1[CH:4]=[CH:5][C:6]([F:21])=[C:7]([CH:9]2[CH2:18][C:17]3[N:16]=[CH:15][CH:14]=[C:13]([CH3:19])[C:12]=3[C:11](=O)[CH2:10]2)[CH:8]=1.[C:22]([NH:25][NH2:26])([NH2:24])=[NH:23].Cl.Cl>C(O)C>[ClH:2].[Cl:2][C:3]1[CH:4]=[CH:5][C:6]([F:21])=[C:7]([CH:9]2[CH2:18][C:17]3[N:16]=[CH:15][CH:14]=[C:13]([CH3:19])[C:12]=3[C:11](=[N:26][NH:25][C:22]([NH2:24])=[NH:23])[CH2:10]2)[CH:8]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 183175987-(5-Chloro-2-fluorophenyl)-4-methyl-5,6,7,8-tetrahydroquinolin-5-one hydrochlorideHCID 178418668HCID 178418668, compound

Product 1

HCID 178428121HCID 178428121, compoundYield 170.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
110 °C

Procedure

To a solution of 7-(5-chloro-2-fluorophenyl)-4-methyl-5,6,7,8-tetrahydroquinolin-5-one hydrochloride (0.6 g) and aminoguanidine hydrochloride (0.233 g) in ethanol (10 ml) was added concentrated hydrochloric acid (0.1 ml), and the mixture was stirred at 110° C. (bath temperature) for 2 hours. The reaction solution was cooled to room temperature, and the crystals were filtered and dried to give 7-(5-chloro-2-fluorophenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline hydrochloride (Compound 171) (0.6 g) as colorless crystals.

Workup

  1. temperatureThe reaction solution was cooled to room temperature
  2. filtrationthe crystals were filtered
  3. customdried

Sources & evidence

ORD record
ord-d03085cdb8864023abc5d5f089f64851
Source dataset
uspto-grants-2002_02
Patent number
US06350749B1

Reaction notes

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