Chlorine → HCID 11266313, compound

HRID 1700856Notes

Reaction equation

HRID 1700856 reaction equation
ClCl.[CH3:3][C:4]1[CH:12]=[C:11](Cl)[C:10]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:9][C:5]=1[C:6]([OH:8])=[O:7]>B(O[O-])=O.[Na+]>[CH3:3][C:4]1[CH:12]=[C:11]([S:14]([CH3:10])(=[O:16])=[O:15])[C:10]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:9][C:5]=1[C:6]([OH:8])=[O:7]

Participants

4

Reactant 2

HCID 24526ChlorineHCID 108244784-chloro-2-methyl-5-(methylsulfonyl)Benzoic acid

Product 1

HCID 11266313HCID 11266313, compound

Reagents, catalysts & solvents 1

HCID 517072Sodium PerborateSolvent

Procedure

in stage c) the chlorine substituent is converted into a second methylsulfonyl group by reacting 2-methyl-4-chloro-5-methylsulfonylbenzoic acid with sodium methylthiolate and then oxidizing the thioether with an oxidizing agent, in particular sodium perborate, to give the corresponding intermediate 2-methyl-4,5-di(methylsulfonyl)benzoic acid,

Sources & evidence

ORD record
ord-dd5b7f99c54e43c696ffb1167c41a27e
Source dataset
uspto-grants-2002_02
Patent number
US06350904B1

Reaction notes

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