HCID 15453526, compound → HCID 15453527, compound

HRID 1700864Notes

Reaction equation

HRID 1700864 reaction equation
[CH:1]([O:4][C:5]1[CH:24]=[CH:23][C:22]([CH:25]=[CH2:26])=[CH:21][C:6]=1[O:7][CH2:8][CH2:9][N:10]1[C:18](=[O:19])[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]1=[O:20])([CH3:3])[CH3:2]>CO.[Pd]>[CH2:25]([C:22]1[CH:23]=[CH:24][C:5]([O:4][CH:1]([CH3:2])[CH3:3])=[C:6]([CH:21]=1)[O:7][CH2:8][CH2:9][N:10]1[C:18](=[O:19])[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]1=[O:20])[CH3:26]

Participants

4

Reactant 1

HCID 15453526HCID 15453526, compound

Product 1

HCID 15453527HCID 15453527, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

0.15 g of 10% palladium-on-charcoal is added to a solution of 0.53 g of 2-[2-(isopropoxy-5-vinylphenoxy)ethyl]isoindole-1,3-dione (1.51 mmol) in 8 ml of methanol. The suspension is stirred under a hydrogen atmosphere for 2 hours, the solid is then removed by filtration on a silica filter, and the solvent is evaporated off. The title product is isolated by crystallization from a cyclohexane/ethyl acetate mixture. 0.53 g of a white solid is obtained:

Workup

  1. customthe solid is then removed by filtration on a silica
  2. filtrationfilter
  3. customthe solvent is evaporated off

Sources & evidence

ORD record
ord-f2f55d2ec3634b00a8a7382176b8941c
Source dataset
uspto-grants-2002_02
Patent number
US06350913B1

Reaction notes

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