HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 4-[4-[2-(N-Dodecyl-N-propylamino]ethoxy]phenyl]-1,1,1-trifluoro-2-butanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | N-Propyl-N-[2-[4-(4,4,4-trifluoro-3,3-dimethoxybut-1-yl)phenoxy]ethyl]dodecylamine | HCID 18319117 | — |
| Reactant | 4-[N-dodecyl-N-[2-[4-(3oxo-4,4,4-trifluorobut-1-yl)phenoxy]ethyl]amino]butanoic acid, ethyl ester | HCID 86757122 | — |
| Product | 4-[4-[2-(N-Dodecyl-N-propylamino]ethoxy]phenyl]-1,1,1-trifluoro-2-butanone | HCID 18319054 | 62% |
Reaction Steps
N-Propyl-N-[2-[4-(4,4,4-trifluoro-3,3-dimethoxybut-1-yl)phenoxy]ethyl]dodecylamine (300 mg, 0.58 mmol) was treated with trifluoroacetic acid as described in the preparation of 4-[N-dodecyl-N-[2-[4-(4,4,4-trifluoro-3-oxobut-1-yl)phenoxy]ethyl]amino]butanoic acid, ethyl ester and afforded the title compound (169 mg, 62%) as a pale yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06350892B1 |
| Source dataset | uspto-grants-2002_02 |
| ORD ID | ord-c257d03876b2414684182cf97b065af7 |
| Source note | uspto-grants-2002_02 |