HRID1700916

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

结构：CCCCCCCCCCCCN(CCC)CCOc1ccc(CCC(OC)(OC)C(F)(F)F)cc1

HCID18319117

未命名化合物

结构：CCCCCCCCCCCCN(CCCC(=O)OCC)CCOc1ccc(CCC(=O)C(F)(F)F)cc1

HCID86757122

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCCCCCN(CCC)CCOc1ccc(CCC(=O)C(F)(F)F)cc1

HCID18319054

未命名化合物

收率 62%

PROCEDURE

实验过程

N-Propyl-N-[2-[4-(4,4,4-trifluoro-3,3-dimethoxybut-1-yl)phenoxy]ethyl]dodecylamine (300 mg, 0.58 mmol) was treated with trifluoroacetic acid as described in the preparation of 4-[N-dodecyl-N-[2-[4-(4,4,4-trifluoro-3-oxobut-1-yl)phenoxy]ethyl]amino]butanoic acid, ethyl ester and afforded the title compound (169 mg, 62%) as a pale yellow oil.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c257d03876b2414684182cf97b065af7
来源数据集: uspto-grants-2002_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06350892B1
来源说明: uspto-grants-2002_02

反应 SMILES

[CH2:1]([N:4]([CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH3:36])[CH2:5][CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][C:16](OC)([O:21]C)[C:17]([F:20])([F:19])[F:18])=[CH:10][CH:9]=1)[CH2:2][CH3:3].FC(F)(F)C(O)=O.C(N(CCCC(OCC)=O)CCOC1C=CC(CCC(=O)C(F)(F)F)=CC=1)CCCCCCCCCCC>>[CH2:25]([N:4]([CH2:5][CH2:6][O:7][C:8]1[CH:9]=[CH:10][C:11]([CH2:14][CH2:15][C:16](=[O:21])[C:17]([F:19])([F:20])[F:18])=[CH:12][CH:13]=1)[CH2:1][CH2:2][CH3:3])[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH3:36]