Trifluoroacetic acid → HCID 59875748, compound

HRID 1700989Notes

Reaction equation

[CH3:1][C:2]([CH3:44])([CH3:43])[C@H:3]([NH:15][C:16]([C@H:18]([CH2:27][CH2:28][CH2:29][C:30]1[CH:35]=[CH:34][C:33]([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)=[C:32]([F:42])[CH:31]=1)[CH2:19][C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])=[O:17])[C:4]([NH:6][C@@H:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH3:8])=[O:5].FC(F)(F)C(O)=O>>[CH3:43][C:2]([CH3:1])([CH3:44])[C@H:3]([NH:15][C:16]([C@H:18]([CH2:27]/[CH:28]=[CH:29]/[C:30]1[CH:35]=[CH:34][C:33]([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)=[C:32]([F:42])[CH:31]=1)[CH2:19][C:20]([O:22][C:23]([CH3:24])([CH3:25])[CH3:26])=[O:21])=[O:17])[C:4]([NH:6][C@@H:7]([C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1)[CH3:8])=[O:5]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 59875787HCID 59875787, compound

Product 1

HCID 59875748HCID 59875748, compoundYield 80%

Procedure

According to the method of Preparation 1, tert-butyl (3R)-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)-6-[3-fluoro-(4-phenyl)phenyl]hexanoate (650 mg, 1.08 mmol) was treated with trifluoroacetic acid at 20° C. for 4 h to give the title compound (470 mg, 80%).

Sources & evidence

ORD record: ord-41fb7ccf47854b31bf62f9d71b93bb0c
Source dataset: uspto-grants-2002_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06350907B1

Reaction notes

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