HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-butyl (3R,5E)-3-({[(1S)-2,2-dimethyl-1-(benzyloxycarbonyl)propyl]amino}carbonyl)-6-(3'-methoxy-2-methylbiphen-4-yl)hex-5-enoate → tert-butyl (3r)-3-({[(1S)-2,2-dimethyl-1-(carboxy)propyl]amino}carbonyl)-6-(3'-methoxy-2-methylbiphen-4-yl)hexanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-butyl (3R,5E)-3-({[(1S)-2,2-dimethyl-1-(benzyloxycarbonyl)propyl]amino}carbonyl)-6-(3'-methoxy-2-methylbiphen-4-yl)hex-5-enoate | HCID 59875766 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | tert-butyl (3r)-3-({[(1S)-2,2-dimethyl-1-(carboxy)propyl]amino}carbonyl)-6-(3'-methoxy-2-methylbiphen-4-yl)hexanoate | HCID 59875740 | 74,741.703% |
Reaction Steps
According to the method of Preparation 19 c), tert-butyl (3R,5E)-3-({[(1S)-2,2-dimethyl-1-(benzyloxycarbonyl)propyl]amino}carbonyl)-6-(3′-methoxy-2-methylbiphen-4-yl]hex-5-enoate (1.040 g, 1.69 mmol) was hydrogenated over 10% palladium on charcoal to give tert-butyl (3R)-3-({[(1S)-2,2-dimethyl-1-(carboxy)propyl]amino}carbonyl)-6-(3′-methoxy-2-methylbiphen-4-yl)hexanoate (664 g, 75%) as a colourless foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06350907B1 |
| Source dataset | uspto-grants-2002_02 |
| ORD ID | ord-fdb9bfcf3b4f4afeb180eb2a68130878 |
| Source note | uspto-grants-2002_02 |