Hydrochloric Acid → HCID 67392363, compound

HRID 17010Notes

Reaction equation

HRID 17010 reaction equation
[F:1][C:2]([F:15])([F:14])[CH2:3][N:4]1[CH2:13][CH2:12][C:7]2(OCC[O:8]2)[CH2:6][CH2:5]1.[ClH:16]>CC(C)=O>[ClH:16].[F:15][C:2]([F:1])([F:14])[CH2:3][N:4]1[CH2:13][CH2:12][C:7](=[O:8])[CH2:6][CH2:5]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 670071628-(2,2,2-Trifluoroethyl)-1,4-dioxa-8-azaspiro[4.5]decane

Product 1

HCID 67392363HCID 67392363, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

8-(2,2,2-Trifluoroethyl)-1,4-dioxa-8-aza-spiro[4.5]decane (3.7 g, 16 mmol) was added to a solution of 5% HCl (45 mL) and acetone (8 mL). After refluxing for 12 h, the solvent was removed to give crude 1-(2,2,2-trifluoroethyl)piperidin-4-one hydrochloride which was used in the next reaction.

Workup

  1. temperatureAfter refluxing for 12 h
  2. customthe solvent was removed

Sources & evidence

ORD record
ord-b8380098cd4f44efafc9c92cbd472c13
Source dataset
uspto-grants-2010_06
Patent number
US07737300B2

Reaction notes

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