HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 2-Bromo-N-[4-chloro-2-(4-hydroxybenzoyl)phenyl]acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Bromoacetyl bromide | HCID 61147 | — |
| Reactant | Methanone, (2-amino-5-chlorophenyl)(4-hydroxyphenyl)- | HCID 11402375 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 2-Bromo-N-[4-chloro-2-(4-hydroxybenzoyl)phenyl]acetamide | HCID 12517306 | — |
Reaction Steps
A solution of 41 g (0.165 mole) 2-amino-5-chloro-4'-hydroxybenzophenone in 800 ml of ether and 200 ml of water was cooled to 5°. The mixture was stirred while 20 ml (0.277 mole) of bromoacetyl bromide and a 20% solution of sodium carbonate were added alternately keeping the solution slightly basic. After 20 min. the reaction mixture was filtered to collect 60 g (about 100%) of product mp 201°-202°. Recrystallization from ethanol gave colorless prisms, mp 201°-203°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04191738 |
| Source dataset | uspto-grants-1980_03 |
| ORD ID | ord-316fd8d237434beea9e09ac7ad5d18aa |
| Source note | uspto-grants-1980_03 |